Interactions of Soft Colloids with Soft Interfaces

 

Understanding how nanoparticles interact with membranes and cells has an enormous impact on one hand for the investigation of their cytotoxicity and on the other hand for the design of a new generation of drug delivery vehicles. In addition, it is a great inspiration for the development of new responsive biomaterials.

We are aiming at an advanced understanding of the interactions of soft responsive model colloids with lipid membranes. This project focuses on the adsorption, wrapping, translocation and organization of fluorescent spherical or anisotropic thermoresponsive microgel particles at the interface of either curved giant unilamellar vesicles or planar bilayer at liquid/liquid interface.

 
  Tuneable adsorption of responsive microgels at the surface of lipid GUVs Copyright: Crassous


Figure 1: Tuneable adsorption of responsive microgels at the surface of lipid GUVs. Top: 20oC, bottom: 40oC. Reproduced from Ref. [1].









Collaborations: Emma Sparr (Lund University, Sweden), Meina Wang, Aleksandra Dabowska, Adriana M. Mihut


Video: „Electroformation of lipid giant unilamellar vesicles (GUVs) in presence of microgels

References
[1] A.M. Mihut, A.P. Dabkowska, J.J. Crassous, P. Schurtenberger, T. Nylander, ACS Nano, 2013, 7, 10752